【近5年来主要研究课题】 1.主持,横向课题,基于靶蛋白降解技术的创新药物开发。 2.主持,抗肿瘤化合物SIPI-ZH-601的临床前研究,上海市“科技创新行动计划”生物医药领域科技支撑项目(14431905900)。 3.主持,横向课题,抗病毒药物的筛选与开发研究。 【近5年来代表性论文】 1.Shaodong Liu, Yang Da, Feng Wang, Renjie Yan, Yongzhi Shu, Pei Lin,Jun Lin*. Targeted selective degradation of Bruton’s tyrosine kinase by PROTACs. Med Chem Res, 2020, 29(4), 802-808. 2.Yang Da, Shaodong Liu, Pei Lin, Feng Wang, Renjie Yan, Yongzhi Shu,Jun Lin*. Design, synthesis, and biological evaluation of small molecule PROTACs for potential anticancer effects. Med Chem Res, 2020, 29(2): 334-340. 3.Liyuan Yang,Jun Lin, Bin Zhou, Yangang Liu, Baoquan Zhu. Activity of compounds fromTaxillus sutchuenensisas inhibitors of HCV NS3 serine protease. Nat Prod Res.2017, 31(4): 487-491. 4.Xianglei Liu,Jun Lin*, Haifeng Hu, Bin Zhou, Baoquan Zhu. Site-specific integration and constitutive expression of key genes intoEscherichia colichromosome increases shikimic acid yields. Enzyme Microb Technol. 2016, 82:96-104. 5.Xianglei Liu,Jun Lin*, Haifeng Hu, Bin Zhou, Baoquan Zhu. Enhanced production of shikimic acid using a multi-gene coexpression inEscherichia coli. Chin J Nat Med, 2016, 14(4):286-293. 6.Xianglei Liu,Jun Lin, Haifeng Hu, Bin Zhou, Baoquan Zhu. De novo biosynthesis of resveratrol by site-specific integration of heterologous genes inEscherichia coli. FEMS Microbiol Lett. 2016, 363(8):fnw061. 7.Liyuan Yang,Jun Lin, Bin Zhou, Yangang Liu, Baoquan Zhu. H1-A, a compound isolated fromFusarium oxysporuminhibits hepatitis C virus (HCV) NS3 serine protease. Chin J Nat Med. 2016, 14(4): 299-302. 8.林军,刘向磊,胡海峰,周斌,朱宝泉.莽草酸生产重组菌株的构建.中国医药工业杂志,2016, 47(5): 537-542. 【近5年主要授权专利】 【主要奖励】 1.一种麦角固醇类化合物的制备方法和纯化方法. 2020/05/19,专利号:ZL 201510104892.4。 2.一种苯基取代的烷基胺的制备方法和纯化方法. 2020/08/18,专利号:201510072702.5。 3.(E)-2,4-二羟基-6-丙烯基苯甲醛及其制备方法和用途,2020/01/10,专利号:ZL 201510766664.3 4.一种生产莽草酸的重组菌株及其制备方法与应用,2019/10/22,专利号:ZL 201510317035.2 5.丙型肝炎病毒NS3/4A蛋白酶及基因、检测抑制剂活性的方法,2019/08/30,专利号:ZL 201510098364.2 6.萘啶酮类化合物、及其制备方法和应用,2019/06/25,专利号:ZL 201610165043.4 7.(E)-4-(3-羟基-1-丙烯基)-2-甲氧基苯酚和(E)-4-(3-羟基-1-丙烯基)邻苯二酚的应用和药物组合物,2019/06/25,专利号:ZL 201510766662.4 8.一种以山梨醇作为碳源提高发酵生产莽草酸产量的方法. 2017/09/01,专利号:ZL 201310356435.5 9.一种二噁英类化合物的制备方法、纯化方法及应用,2018/01/05,专利号:ZL 201410036260.4 10.一种3-甲硫基丙酸的制备方法. 2017/06/06,专利号:ZL 201310106638.9 11.Platinum (II) compound, preparation method therefor, and pharmaceutical composition and application thereof. 2017/05/16,美国,US9650403 B2 12.一种铂(II)配合物、其制备方法、药物组合物及应用,2017/01/04,专利号:ZL 201410103727.2 13.一种3-脱氢奎尼酸合成酶突变体及其基因和应用,2016/04/20,专利号:ZL 201310157144.3 |