科学研究情况简介 |
【近年来获得的学术科研成果】 近年来主要从事有机化学合成的研究,近五年以通讯作者身份在《Org. Lett.》、《Org. Chem. Front.》、《J. Org. Chem.》和《Chinese Chem. Lett.》等国际期刊上发表SCI论文20余篇,申请国际和国内专利10余件(其中已获授权3件)。 【近年来主要研究课题】 1. BK20150129,江苏省自然科学基金-青年,主持,已结题 2. 江苏省双创博士《境外世界名校类》,主持人 3. JUSRP11546,江南大学自主科研计划,主持人 另外,主持多项横向课题。 【近年来主要论文代表作】(*为通讯作者) J. Yuan, R. Peng, D. Cheng,* L. H. Zou,* L. Yuan,* Chem. Asian J. 2021, 16, 342-347 (JCR三区). Revealing minor pH changes of mitochondria by a highly sensitive molecular fluorescent probe. K. Shi, H. Zhu, F. Ren, S. Liu, Y.-Y. Song, W. Li,* L.-H. Zou,* Eur. J. Org. Chem. 2021, 1003-1006 (JCR三区). Copper-catalyzed [3+2+1] annulation of anthranils with phenylacetaldehydes: Synthesis of 8-acylquinolines. 1. S. Zhu, K. Shi, H. Zhu, Z.-K. Jia, X.-F. Xia, D. Wang, L.-H. Zou*, Org. Lett. 2020, 22, 1504-1509 (JCR一区). Copper-catalyzed annulation or homocoupling of sulfoxonium ylides: synthesis of 2,3-diaroylquinolines or α,α,β-tricarbonyl sulfoxonium ylides. 2. L.-H. Zou*, H. Zhu, S. Zhu, K. Shi, C. Yan, P.-G. Li, J. Org. Chem. 2019, 84, 12301-12313 (JCR二区). Copper-catalyzed ring-opening/reconstruction of anthranils with oxo-compounds: synthesis of quinoline derivatives. 3. P.-G. Li, C. Yan, S. Zhu, S.-H. Liu, L.-H. Zou*, Org. Chem. Front. 2018, 5, 3464-3468 (JCR一区). Direct construction of benzimidazo[1,2-c]quinazolin-6-ones via metal-free oxidative C-C bond cleavage. 4. L.-H. Zou,* C. Zhao, P.-G. Li, Y. Wang, J. Li*, J. Org. Chem. 2017, 82, 12892-12898 (JCR二区). Transition-metal-free C−S bond formation: synthesis of polysubstituted diaryl sulfides and α-thioarylcarbonyl compounds. 5. L.-H. Zou*, M. Fan, L. Wang*, C. Liu*, Chin. Chem. Lett. 2019, 31, 1911-1913 (JCR一区). Hetero diacylation of 1,1-diborylalkanes: practical synthesis of 1,3-diketones. 6. L.-H. Zou*, C. Yan, K. Shi, L. Su, S. Zhu, Z.-K. Jia, Q. Wang*, Eur. J. Org. Chem. 2019, 7725-7729 (JCR三区). Copper-catalyzed C–C bond cleavage/double cyclization of α-ketoamides with o-phenylene diamines: synthesis of benzimidazo[1,2-c]quinazolin-6-ones. 7. P.-G. Li, H. Zhu, M. Fan, C. Yan, K. Shi, X.-W. Chi, L.-H. Zou*, Org. Biomol. Chem. 2019, 17, 5902-5907 (JCR三区). Copper-catalyzed coupling of anthranils and α-keto acids: direct synthesis of α-ketoamides. 8. Y. Wang, S. Zhu, L.-H. Zou*, Eur. J. Org. Chem. 2019, 2179-2201 (JCR三区). Recent advances in direct functionalization of quinones. 9. L.-H. Zou,* Y.-C. Li, P.-G. Li, J. Zhou, Z. Wu*, Eur. J. Org. Chem. 2018, 5639-5643 (JCR三区). Solvent-controlled α-monobromination, α,α-dibromination or imidation of 1,3-diketones with N-bromosuccinimide. (VIP paper) 10. P.-G. Li*, Y. Yang, S. Zhu, H.-X. Li, L.-H. Zou*, Eur. J. Org. Chem. 2019, 73-76. Pd-catalyzed regioselective direct double C−H arylation of 6,7-benzindoles. (VIP paper) 11. P.-G. Li, Y.-C. Li, T. Zhu, L.-H. Zou,* Z. Wu*, Eur. J. Org. Chem. 2017, 6081-6084 (JCR三区). Hydroxysulfonylation of quinones with aryl(alkyl)sulfonyl hydrazides for the synthesis of 1,4-dihydroxy-2-aryl(alkyl)sulfonylbenzenes. 12. Z. Wu,* Y.-C. Li, W.-Z. Ding, T. Zhu, S.-Z. Liu, X. Ren, L.-H. Zou*, Asian J. Org. Chem. 2016, 5, 625-628 (JCR三区). Copper-catalyzed regioselective sulfenylation of indoles with arylsulfonyl chlorides. L.-H. Zou, A. R. Philipps, G. Raabe, D. Enders*, Chem. Eur. J. 2015, 21, 1004-1008. Asymmetric synthesis of fully substituted cyclopentane-oxindoles through an organocatalytic triple Michael domino reaction. 13. L.-H. Zou, J. Mottweiler, D. L. Priebbenow, J. Wang, J. A. Stubenrauch, C. Bolm*, Chem. Eur. J. 2013, 19, 3302-3305 (Highlighted by P. Knochel, N. M. Barl, Synfacts, 2013, 9, 0537.). Mild copper-mediated direct oxidative cross-couplings of 1,3,4-oxadiazoles with polyfluoroarenes using dioxygen as oxidant. 14. L.-H. Zou, A. J. Johansson, E. Zuidema, C. Bolm*, Chem. Eur. J. 2013, 19, 8144-8152. Mechanistic insights into the copper-catalyzed Sonogashira-Hagihara-type cross-coupling reactions: sub-mol% catalyst loadings and ligand effects. L.-H. Zou, D. L. Priebbenow, L. Wang, C. Bolm*, Adv. Synth. Catal. 2013, 355, 2558-2563. Copper-catalyzed synthesis of a-thiophenyl carbonyl compounds through S-S bond cleavage and C-C bond activation. 1. L.-H. Zou, J. Reball, J. Mottweiler, C. Bolm*, Chem. Commun. 2012, 48, 11307-11309. Transition metal-free direct C-H bond thiolation of 1,3,4-oxadiazoles and related heteroarenes. 2. L.-H. Zou, Z.-B. Dong, C. Bolm*, Synlett 2012, 23, 1613-1616. Metal-free phosphorylations of 1,3,4-oxadiazoles and related heterocycles. 【主要授权国家发明专利】 一种苯并咪唑并喹唑啉酮化合物的合成方法,专利号:ZL 2019 1 0675411.3。 一种邻位醛基的α-酮酰胺类化合物的合成方法,专利号:ZL 2019 1 0122907.5。 【主要科研奖励】 江苏省“双创博士” |