科学研究情况简介 |
【近年来获得的学术科研成果】 近年来发表SCI论文20余篇,主持多项国家自然科学基金和企业合作项目,申请发明专利8项。 【近年来主要研究课题】 [1] 国家自然科学基金青年项目,主持。 [2] 中国博士后科学基金面上(一等资助)项目,主持。 [3] 江苏省自然科学基金面上项目,主持。 [4] 山东省博士后创新项目,主持。 [5] 中央高校基本科研业务经费培育项目,主持。 [6] 胶原基修复凝胶的研发,企业项目,主持。 [7] 缓释微丸的研发,企业项目,主持。 [8] 透明质酸冻干制剂的研发,企业项目,主持。 【近年来主要论文代表作】 发表SCI论文20余篇,代表作如下:
[1] Qiu L, Qiao M, Chen Q, et al. Enhanced Effect of pH-Sensitive Mixed Copolymer Micelles for Overcoming Multidrug Resistance of Doxorubicin. Biomaterials. 2014, 35(37): 9877-9887. [2] Qiu L, Li Z, Qiao M, et al. Self-assembled pH-responsive Hyaluronic Acid-g-poly (L-histidine) Copolymer Micelles for Targeted Intracellular Delivery of Doxorubicin. Acta Biomaterialia. 2014, 10 (5): 2024-2035. [3] Qiu L, Hu Q, Cheng L, et al. cRGDyK modified pH responsive nanoparticles for specific intracellular delivery of doxorubicin. Acta Biomaterialia. 2016, 30: 285-298. [4] Chen Q, Long M, Qiu L*, et al. Decoration of pH-sensitive copolymer micelles with tumor-specific peptide for enhanced cellular uptake of doxorubicin. Int J Nanomedicine. 2016:11 5415–5427. [5] Qiu L, Zhu M, Huang Y, et al. Mechanisms of cellular uptake with hyaluronic acid-octadecylamine micelles as drug delivery nanocarriers. RSC advances, 2016, 6, 9896–39902. [6] Qiu L, Zhu M, Gong K, et al. pH-Sensitive degradable polymeric micelles for bio-triggered targeted anti-tumor drug delivery, Journal of Controlled Release. 2017, 259: e86-e87. [7] Qiu L, Zhu M, Gong K, et al. pH-triggered degradable polymeric micelles for targeted anti-tumor drug delivery. Mater Sci Eng C Mater Biol Appl. 2017, 78: 912-922. [8] Ahmed KS, Hussein SA, Ali AH, Korma SA, Qiu L *, Chen J*. Liposome: composition, characterisation, preparation, and recent innovation in clinical applications. J Drug Target. 2018, 15: 1-20. [9] Qiu L, Ge L, Long M, et al. Designing heparan sulfate-based biocompatible polymers and their application for intracellular stimuli-sensitive drug delivery. Mater Sci Eng C Mater Biol Appl. 2019, 94: 465-476. [10] Ahmed KS, Shan X, Mao J, Qiu L*, Chen J*. Derma roller® microneedles-mediated transdermal delivery of doxorubicin and celecoxib co-loaded liposomes for enhancing the anticancer effect. Mater Sci Eng C Mater Biol Appl. 2019, 99:1448-1458. [11] Shan X, Mao J, Long M, Ahmed KS, Sun C, Qiu L*, Chen J*. Influence of polyethylene glycol molecular weight on the anticancer drug delivery of pH-sensitive polymeric micelle. J Appl Polym Sci. 2019, 136 (32): 47854. [12] Qiu L, Shan X, Long M, et al. Elucidation of cellular uptake and intracellular trafficking of heparosan polysaccharide-based micelles in various cancer cells. Int J Biol Macromol. 2019, 130:755-764. [13] Ahmed KS, Sun C, Shan X, Mao J, Qiu L*, Chen J*. Liposome-based codelivery of celecoxib and doxorubicin hydrochloride as a synergistic dual-drug delivery system for enhancing the anticancer effect. J Liposome Res. 2020, 30(3): 285-296. [14] Qiu L, Ge L, Long M, et al. Redox-responsive biocompatible nanocarriers based on novel heparosan polysaccharides for intracellular anticancer drug delivery. Asian J Pharm Sci. 2020, 15(1): 83-94. [15] Song JL, Huang ZQ, Mao J, Chen WJ, Wang B, Yang FW, Liu SH, Zhang HJ, Qiu L*, Chen JH*. A facile synthesis of uniform hollow MIL-125 titanium-based nanoplatform for endosomal esacpe and intracellular drug delivery. Chem Eng J, 2020, 396: 125246. [16] Long M, Liu S, Shan X, Mao J, Yang F, Wu X, Qiu L*, Chen J*. Self-assembly of pH-sensitive micelles for enhanced delivery of doxorubicin to melanoma cells. J Drug Deliv Sci Tec, 2020, 59, 101859. [17] Maqsood M, Kang M, Wu X, Chen J, Teng L*, Qiu L*. Adult mesenchymal stem cells and their exosomes: Sources, characteristics, and application in regenerative medicine. Life Sci, 2020, 256, 118002. [18] Ji Q, Zhang H, Zhang X, Ma Q, Teng L*, Qiu L*. Hydrosoluble collagen based biodegradable hybrid hydrogel for biomedical scaffold. J Biomater Sci Polym Ed, 2020, 31(17): 2199-2219. [19] Mao J1, Qiu L1, Ge L, Zhou J, Ji Q, Yang Y, Long M, Wang D, Teng L*, Chen J. Overcoming multidrug resistance by intracellular drug release and inhibiting p-glycoprotein efflux in breast cancer. Biomed Pharmacother, 2021, 134: 111108. 【申请国家发明专利】
[1]一种复方坦洛新和非那雄胺控释片及制备方法. 王东凯, 邱立朋. 公开号: CN 101703512A. [2]复方坦洛新和非那雄胺缓释胶囊及其制备方法. 王东凯, 邱立朋. 公开号: CN101703511A. [3]一种坦洛新和非那雄胺复方缓释片及其制备方法. 王东凯, 邱立朋. 公开号:CN 101703510A. [4]一种肝素前体多糖聚合物及其制备方法和应用. 邱立朋, 陈敬华, 葛璐, 毛静. 公开号: CN201811562526.3.
【主要科研奖励】 全国挑战杯优秀指导教师 江南大学“青年至善学者” 高等学校科学研究技术进步二等奖 中国轻工业联合会科技进步二等奖 中国商业联合会科技进步一等奖 |