科学研究情况简介 |
【近年来获得的学术科研成果】 近年来主持国家自然科学基金1项,江苏省自然科学基金1项,教育部“留学回国人员科研启动基金”1项。在ACS Applied Materials & Interfaces, Nanoscale等期刊发表SCI论文30余篇。申请国际专利1项。 【近年来主要研究课题】 [1] 噬菌体展示肽功能化糖原精准递送CpG ODN逆转Th1/Th2免疫应答失衡治疗花粉症的研究(21907041),国家自然科学基金,26万元,主持 [2]氮化硼纳米球提高CpG ODNs的免疫刺激活性联合阿霉素协同抗肿瘤的研究(BK20170202),江苏省自然科学基金,20万元,主持 [3]智能型CpG ODN/阿霉素纳米载药体系的构建及其靶向抗肿瘤研究,教育部“留学回国人员科研启动基金”,3万元,主持 [4]基于氧化石墨烯的CpG ODN高效传输系统的构建及其在肿瘤免疫治疗中的应用,中央高校基本科研业务经费, 8万元,主持 【近年来主要论文代表作】(*为通讯作者) [1] H. Zhang, W. Chen, K. Gong, J. Chen, Nanoscale Zeolitic Imidazolate Framework-8 as Efficient Vehicles for Enhanced Delivery of CpG Oligodeoxynucleotides,ACS Applied Materials & Interfaces, 2017 (9) 31519-31525. [2]H. Zhang, D. Huang, C. Yuan, T. Yan, S. Feng, H. Nakanishi, X.-D. Gao, Genetically engineered yeast spores as chitosan microspheres for intracellular delivery of immunostimulatory CpG oligodeoxynucleotides,Journal of Controlled Release, 2017 (259) e50. [3]H. Zhang, T. Cheng, L. Lai, S. Deng, R. Yu, L. Qiu, J. Zhou, G. Lu, C. Zhi, J. Chen, BN nanospheres functionalized with mesoporous silica for enhancing CpG oligodeoxynucleotide-mediated cancer immunotherapy,Nanoscale10 (2018) 14516-14524. [4] H. Zhang, T. Yamazaki, C. Zhi, N. Hanagata, Identification of a boron nitride nanosphere-binding peptide for the intracellular delivery of CpG oligodeoxynucleotides,Nanoscale, 2012 (4) 6343-6350. [5]H. Zhang, T. Yan, S. Feng, D. Huang, C. Zhi, X.-D. Gao, Mesoporous silica functionalized boron nitride nanospheres for enhancing the immunostimulatory and antitumor effects of CpG ODNs,Nanomedicine: Nanotechnology, Biology and Medicine14 (2018) 1823-1824. [6] H. Zhang, C. Zhi, X. Gao, Polyethyleneimine-functionalized boron nitride nanospheres as an efficient carrier for enhancing the immunostimulatory effect of CpG oligodeoxynucleotides,Nanomedicine: Nanotechnology, Biology and Medicine, 2016 (12) 540. [7]H. Zhang, L. Lai, Y. Wang, B. Ye, S. Deng, A. Ding, L. Teng, L. Qiu, J. Chen, Silk fibroin for CpG oligodeoxynucleotides delivery,ACS Biomaterials Science & Engineering2019 (11), 6082-6088 [8] H. Zhang, S. Chen, C. Zhi, T. Yamazaki, N. Hanagata, Chitosan-coated boron nitride nanospheres enhance delivery of CpG oligodeoxynucleotides and induction of cytokines,International Journal of Nanomedicine, 2013 (8) 1783-1793. [9]H. Zhang, S. Feng, T. Yan, C. Zhi, X.-D. Gao, N. Hanagata, Polyethyleneimine-functionalized boron nitride nanospheres as efficient carriers for enhancing the immunostimulatory effect of CpG oligodeoxynucleotides,International Journal of Nanomedicine, 2015 (10) 5343-5353. [10]H. Zhang, X.-D. Gao, Nanodelivery systems for enhancing the immunostimulatory effect of CpG oligodeoxynucleotides,Materials Science and Engineering: C, 2017 (70) 935-946. [11]H. Zhang, T. Yan, S. Xu, S. Feng, D. Huang, M. Fujita, X.-D. Gao, Graphene oxide-chitosan nanocomposites for intracellular delivery of immunostimulatory CpG oligodeoxynucleotides,Materials Science and Engineering: C, 2017 (73) 144-151. [12]H. Zhang, M. Peng, T. Cheng, P. Zhao, L. Qiu, J. Zhou, G. Lu, J. Chen, Silver nanoparticles-doped collagen–alginate antimicrobial biocomposite as potential wound dressing,Journal of Materials Science53 (2018) 14944-14952. [13]张慧杰,朱向东,王辛龙,范红松,张兴栋,烧结方式对羟基磷灰石陶瓷颗粒性能和蛋白吸附的影响,无机材料学报(2010) 770-774. [14] T. Cheng, J. Miao, D. Kai,H. Zhang*, Polyethylenimine-Mediated CpG Oligodeoxynucleotide Delivery Stimulates Bifurcated Cytokine Induction,ACS Biomaterials Science & Engineering, 2018 (4) 1013-1018. [15] S. Feng, H. Li, Y. Ren, C. Zhi, Y. Huang, F. Chen*,H. Zhang*, RBC membrane camouflaged boron nitride nanospheres for enhanced biocompatible performance,Colloids and Surfaces B: Biointerfaces190 (2020) 110964. [16] S. Naz, M. Wang, Y. Han, B. Hu, L. Teng, J. Zhou*,H. Zhang*, J. Chen, Enzyme-responsive mesoporous silica nanoparticles for tumor cells and mitochondria multistage-targeted drug delivery,International Journal of Nanomedicine14 (2019) 2533-2542. [17] S. Feng,H. Zhang*, T. Yan, D. Huang, C. Zhi, H. Nakanishi*, X.-D. Gao, Folate-conjugated boron nitride nanospheres for targeted delivery of anticancer drugs,International Journal of Nanomedicine, 2016 (11) 4573-4582. [18] S. Feng,H. Zhang*, C. Zhi, X.-D. Gao, H. Nakanishi*, pH-responsive charge-reversal polymer-functionalized boron nitride nanospheres for intracellular doxorubicin delivery,International Journal of Nanomedicine, 2018 (13) 641-652. [19] T. Yan,H. Zhang*, D. Huang, S. Feng, M. Fujita, X.-D. Gao*, Chitosan-Functionalized Graphene Oxide as a Potential Immunoadjuvant,Nanomaterials, 2017 (7) 59. 【主要发明专利】 1.藤田盛久;金则成;喜多岛敏彦;张慧杰;高晓冬.用于生产糖蛋白的动物细胞株及方法、糖蛋白及其用途.国际专利,PCT/CN2018/084551 2.许丹;于锐汐;张波;张渲聆;曹均洋;张宁珊;张慧杰;陈敬华.海藻酸钠/胶原/石墨相氮化碳纳米片光催化抗菌膜的制备.中国专利,CN110169979A 3.藤田盛久;金则成;喜多岛敏彦;张慧杰;高晓冬.用于生产糖蛋白的动物细胞株及方法、糖蛋白及其用途.中国专利,CN108795871A 【主要奖励】 2015药明康德奖教金 2018-2019江南大学至善青年学者 |