科学研究情况简介 |
【近5年来主要研究课题】 1. 智能多肽聚合物胶束用于抗癌药物的高效递送 2. 全活性不饱和脂肪酸胶束与光动力学疗法/细胞铁死亡结合用于癌症治疗 3. 靶向 m6A 甲基化修饰机制或免疫相关的抗癌药物开发 4. 白血病、肝癌、乳腺癌等癌症发生过程中相关致癌基因的作用机制探究 【近5年来代表性论文】 第一作者及共同第一作者论文： 1. Su R#, Dong L#, Li Y#, Gao M#, et al. Targeting FTO suppresses cancer stem cell maintenance and immune evasion. Cancer Cell. 2020, 38: 1-18. (SCI:1区, IF: 26.602) 2. Gao M, Deng J, Liu F, Fan A, Wang Y, Wu H, Ding D, Kong D, Wang Z, Peer D, Zhao Y*. Triggered ferroptotic polymer micelles for reversing multidrug resistance to chemotherapy. Biomaterials. 2019, 223: 119486. (SCI:1区, IF: 10.317) 3. Gao M, Meng X, Guo X, Zhu J, Fan A, Wang Z, Zhao Y*. All-active antitumor micelles via triggered lipid peroxidation. Journal of Controlled Release. 2018, 286: 381-393. (SCI:1区, IF: 7.94) 4. Tao R#, Gao M#, Liu F, Guo X, Fan A, Ding D, Kong D, Wang Z, Zhao Y*. Alleviating the liver toxicity of chemotherapy via pH-responsive hepatoprotective prodrug micelles. ACS Applied Materials & Interfaces. 2018, 10(26): 21836-21846. (SCI:1区, IF: 8.758) 5. Meng X#, Gao M#, Deng J, Lu D, Fan A, Ding D, et al. Self-immolative micellar drug delivery: The linker matters. Nano Research. 2018, 11(12): 6177-6189. (SCI:1区, IF: 8.183) 6. Gao M, Deng J, Chu H, Tang Y, Wang Z, Zhao Y*, Li G*. Stereoselective stabilization of polymeric vitamin E conjugate micelles. Biomacromolecules. 2017, 18: 4349-4356. (SCI:1区, IF: 6.092) 7. Li X#, Gao M#, Xin K, Zhang L, Ding D, et al. Singlet oxygen-responsive micelles for enhanced photodynamic therapy. Journal of Controlled Release. 2017, 260: 12-21. (SCI:1区, IF: 7.94) 8. Gao M, Chen C, Fan A, Wang Z, Zhao Y*. Stimuli-responsive polymer-curcumin conjugate micelles: residual cytotoxicity analysis. Nanomedicine Nanotechnology Biology & Medicine. 2016, 12(2): 468-468. (SCI:2区, IF: 5.182) 其他作者论文： 1. Qing Y, Dong L, Gao L, Li C, Li H, Prince E, Tan B, Deng X, Wetzel C, Shen C, Gao M, Chen Z, Li W, Zhang B, Braas D, Hoeve J, et al. R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6A/PFKP/LDHB axis. Molecular Cell. 2021, 81: 1-18. (SCI:1区, IF: 15.584) 2. Su R, Dong L, Li Y, Han L, Gao M, et al. Effective novel Fto inhibitors show potent anti-cancer efficacy and suppress drug resistance. Blood. 2019, 134: 233. (SCI:1区, IF: 17.543) 3. Deng J, Liu F, Wang L, An Y, Gao M, Wang Z, Zhao Y*. Hypoxia-and singlet oxygen-responsive chemo-photodynamic micelles featured with glutathione depletion and aldehyde production. Biomaterials Science. 2019, 7(1): 429-441. (SCI:2区, IF: 6.183) 4. Chen C, Zhao J, Gao M, Meng X, Fan A, Wang Z, Zhao Y*. Photo-triggered micelles: simultaneous activation and release of microtubule inhibitors for on-demand chemotherapy. Biomaterials Science. 2018, 6: 511-518. (SCI:2区, IF: 6.183) 【近5年主要授权专利】 1. 赵燕军、王征、高敏，超稳定纳米药物载体 mPEG-PGlu(D)-VE(D)及制备方法及用途，专利号：CN201610615003.5，授权日：2020.03.17 2. 赵燕军、王征、曹延武、陈超、高敏、付运兰，一种具有氧化还原敏感的姜黄素前药胶束、胶束单体及其制备方法，专利号：CN201410008911.9，授权日：2016.09.16 3. 赵燕军、王征、刘瑞红、曹延武、陈超、高敏，一种 pH 及温度超敏感性树枝状大分子药物载体三代半及其制备方法，专利号：CN201310755518.1，授权日：2017.02.15 4. 赵燕军、王征、刘瑞红、曹延武、陈超、高敏，一种 pH 及温度超敏感性树枝状大分子药物载体（2.5 代）及其制备方法，专利号：CN201310755965.7，授权日： 2016.04.13 【主要奖励】 研究生国家奖学金（2015年） 中国药学大会优秀论文（2015年） 教育部公派留学奖学金（2018年） 研究生国家奖学金（2019年） 天津市创新奖学金（2019年） |
