科学研究情况简介 |
【近年来获得的学术科研成果】 【近年来主要研究课题】 1. 近红外/红外（双光子）荧光探针分子在生物体内重金属离子（Pd2+和Hg2+）和重要生物酶（β-galactosidase和CYP1A）的荧光成像检测的理论设计研究。 2. 用于复杂生物体系的新型生物正交试剂的理论研究。 3. 天然[6+4]环加成酶选择性以及反应机理的动力学理论研究。 【近年来主要论文代表作】 1. Chun Zhang, Ai-Min Ren, Jing-Fu Guo, Dan Wang, Li-Ying Yu. Theoretical prediction and investigation of 1,8-naphthalimide-based two-photon fluorescent probes for detecting Cytochrome P450 1A with separated fluorescence signal. Physical Chemistry Chemical Physics, 2018, 20, 13290-13305. 2. Chun Zhang, Xin Wang, Peiyuan Yu, Yong Liang. The Dynamical Trajectory study for a kind of Transannular [6 + 4] and Ambimodal Cycloaddition in the Biosynthesis of Heronamide. Journal of Organic Chemistry. 2020, 85, 9440−9445. 3. Zhuzhou Shao, Chun Zhang（共一）, Xiaohua Zhu, Yajun Wang, Wenyuan Xu, Yu Chen, Xiaoming Wang, Hailiang Zhu, Yong Liang. Design of a 1,8-naphthalimide-based OFF-ON type biorthogonal reagent for fluorescent imaging in live cells. Chinese Chemical Letters, 2019, 30, 2169−2172. 4. Chun Zhang, Lu-Yi Zou, Dan Wang, Li Zhang, Ai-Min Ren. A theoretical investigation and design of fluorescent probes with large two-photon absorption cross-sections and dual signaling behavior for mercury ions in biological system. Journal of Photochemistry and Photobiology A-Chemistry, 2017, 332, 440−452. 5. Chun Zhang, Dan Wang, Li Zhang, Jing-Fu Guo, Ai-Min Ren. Theoretical investigation and design of two-photon fluorescent probes for visualizing β-galactosidase activity in living cells. RSC Advances, 2016, 6, 70960−70971. 6. Chun Zhang, Jing-Fu Guo, Ai-Min Ren, Dan Wang. A theoretical investigation on two-photon absorption and fluorescent properties of coumarin-based derivatives for Pd2+ detection. RSC Advances, 2017, 7, 49505−49517. 【主要授权国家发明专利】 |
