科学研究情况简介 |
【近年来获得的学术科研成果】 近年来发表SCI论文20余篇，主持多项国家自然科学基金和企业合作项目，申请发明专利8项。 【近年来主要研究课题】 [1]基于Heparosan多糖长循环多功能聚合物胶束的构建及作用机制研究，国家自然科学基金-青年项目，主持。 [2]抗癌中药创新纳米制剂的制备及作用研究，中国博士后科学基金面上（一等资助）项目，主持。 [3] Heparosan多糖靶向递送系统的构建及增强肿瘤基因免疫治疗研究，江苏省自然科学基金-面上项目，主持。 [4] pH敏感靶向聚合物胶束及其逆转多药耐药的研究，中央高校基本科研业务经费培育项目，主持。 [5]胶原基修复凝胶的研发，企业项目，主持。 [6]缓释微丸的研发，企业项目，主持。 [7]玻尿酸冻干品的研发，企业项目，主持。 【近年来主要论文代表作】 发表SCI论文20余篇，代表作如下： [1]Qiu L, Qiao M, Chen Q, et al.Enhanced Effect of pH-Sensitive Mixed Copolymer Micelles for Overcoming Multidrug Resistance of Doxorubicin. Biomaterials. 2014, 35(37): 9877-9887. (IF 10.317) [2]Qiu L, Li Z, Qiao M, et al.Self-assembled pH-responsive Hyaluronic Acid-g-poly (L-histidine) Copolymer Micelles for Targeted Intracellular Delivery of Doxorubicin. Acta Biomaterialia. 2014, 10 (5): 2024-2035. (IF 7.242) [3]Qiu L, Hu Q, Cheng L, et al.cRGDyK modified pH responsive nanoparticles for specific intracellular delivery of doxorubicin. Acta Biomaterialia. 2016, 30: 285-298. (IF 7.242) [4] Chen Q, Long M,Qiu L*, et al.Decoration of pH-sensitive copolymer micelles with tumor-specific peptide for enhanced cellular uptake of doxorubicin. Int J Nanomedicine. 2016:11 5415–5427. (IF 5.115) [5]Qiu L, Zhu M, Huang Y, et al.Mechanisms of cellular uptake with hyaluronic acid-octadecylamine micelles as drug delivery nanocarriers. RSC advances, 2016, 6, 9896–39902. (IF 3.119) [6]Qiu L, Zhu M, Gong K, et al.pH-Sensitive degradable polymeric micelles for bio-triggered targeted anti-tumor drug delivery, Journal of Controlled Release. 2017, 259: e86-e87. (IF 7.727) [7]Qiu L, Zhu M, Gong K, et al.pH-triggered degradable polymeric micelles for targeted anti-tumor drug delivery. Mater Sci Eng C Mater Biol Appl. 2017, 78: 912-922. (IF 5.88) [8] Ahmed KS, Hussein SA, Ali AH, Korma SA,QiuL *, Chen J*. Liposome: composition, characterisation, preparation, and recent innovation in clinical applications. J Drug Target. 2018, 15: 1-20. (IF 3.38) [9]Qiu L, Ge L, Long M, et al. Designing heparan sulfate-based biocompatible polymers and their application for intracellular stimuli-sensitive drug delivery. Mater Sci Eng C Mater Biol Appl. 2019, 94: 465-476. (IF 5.88) [10] Ahmed KS, Shan X, Mao J,Qiu L*, Chen J*. Derma roller® microneedles-mediated transdermal delivery of doxorubicin and celecoxib co-loaded liposomes for enhancing the anticancer effect.Mater Sci Eng C Mater Biol Appl.2019, 99:1448-1458. (IF 5.88) [11] Shan X, Mao J, Long M, Ahmed KS, Sun C,Qiu L*, Chen J*. Influence of polyethylene glycol molecular weight on the anticancer drug delivery of pH-sensitive polymeric micelle.J Appl Polym Sci. 2019, 136 (32): 47854. (IF 2.52) [12]Qiu L, Shan X, Long M, et al. Elucidation of cellular uptake and intracellular trafficking of heparosan polysaccharide-based micelles in various cancer cells. Int J Biol Macromol. 2019, 130:755-764. (IF 5.162) [13] Ahmed KS, Sun C, Shan X, Mao J,Qiu L*, Chen J*. Liposome-based codelivery of celecoxib and doxorubicin hydrochloride as a synergistic dual-drug delivery system for enhancing the anticancer effect. J Liposome Res. 2020, 30(3): 285-296. (IF 2.455) [14]Qiu L, Ge L, Long M, et al. Redox-responsive biocompatible nanocarriers based on novel heparosan polysaccharides for intracellular anticancer drug delivery. Asian J Pharm Sci. 2020, 15(1): 83-94. (IF 3.968) [15] Song JL, Huang ZQ, Mao J, Chen WJ, Wang B, Yang FW, Liu SH, Zhang HJ,Qiu LP*, Chen JH*. A facile synthesis of uniform hollow MIL-125 titanium-based nanoplatform for endosomal esacpe and intracellular drug delivery.Chem Eng J, 2020, 396: 125246. (IF 10.652) [16] Long M, Liu S, Shan X, Mao J, Yang F, Wu X,Qiu L*, Chen J*. Self-assembly of pH-sensitive micelles for enhanced delivery of doxorubicin to melanoma cells. J Drug Deliv Sci Tec, 2020, 59, 101859. (IF 2.734) [17] Maqsood M, Kang M, Wu X, Chen J, Teng L*,Qiu L*. Adult mesenchymal stem cells and their exosomes: Sources, characteristics, and application in regenerative medicine. Life Sci, 2020, 256, 118002. (IF 3.647) [18] Ji Q, Zhang H, Zhang X, Ma Q, Teng L*,Qiu L*. Hydrosoluble collagen based biodegradable hybrid hydrogel for biomedical scaffold. J Biomater Sci Polym Ed, 2020, 31(17): 2199-2219. (IF 2.69) [19] Mao J1,Qiu L1, Ge L, Zhou J, Ji Q, Yang Y, Long M, Wang D, Teng L*, Chen J. Overcoming multidrug resistance by intracellular drug release and inhibiting p-glycoprotein efflux in breast cancer. Biomed Pharmacother, 2021, 134: 111108. (IF 4.545) 【申请国家发明专利】 [1]一种复方坦洛新和非那雄胺控释片及制备方法.王东凯,邱立朋.公开号: CN 101703512A. [2]复方坦洛新和非那雄胺缓释胶囊及其制备方法.王东凯,邱立朋.公开号: CN101703511A. [3]一种坦洛新和非那雄胺复方缓释片及其制备方法.王东凯,邱立朋. CN 101703510A. [4]一种肝素前体多糖聚合物及其制备方法和应用.邱立朋,陈敬华,葛璐,毛静.公开号: CN201811562526.3. 【主要科研奖励】 全国挑战杯优秀指导教师 江南大学“青年至善学者” 高等学校科学研究技术进步二等奖 中国轻工业联合会科技进步二等奖 中国商业联合会科技进步一等奖 |
