科学研究情况简介 |
【近5年来主要研究课题】 1)基于基因融合技术或纳米技术开展肿瘤微环境敏感型递药系统的研发 2)以生物大分子为基质开发仿生类材料用于生物组织修复或重建 【近5年来代表性论文】 1)Juan Zhou, Yanzhe Wu, Xihe Zhang, Jiahui Lai, Yuanli Li, Jian Xing, Liping Teng*, and Jinghua Chen*, Enzyme Catalyzed Hydrogel as Versatile Bioadhesive for Tissue Wound Hemostasis, Bonding, and Continuous Repair, Biomacromolecules 2021, 22, 4, 1346-1356. 2)Huan Xu*,Juan Zhou, Karin Odelius, Zhijun Guo, Xin Guan, and Minna Hakkarainen*, Nanostructured Phase Morphology of a Biobased Copolymer for Tough and UV-Resistant Polylactide, ACS Appl. Polym. Mater. 2021, 3, 4, 1973-1982. 3)Mingyu Wang, Li Zhang, Yanfei Cai, Yang Yang, Lipeng Qiu, Yiting Shen, Jian Jin,Juan Zhou*, and Jinghua Chen*, Bioengineered Human Serum Albumin Fusion Protein as Target/Enzyme/pH Three-Stage Propulsive Drug Vehicle for Tumor Therapy. ACS Nano 2020, 14, 12, 17405-17418. 4)Juan Zhou, Yuning Han, Yang Yang, Li Zhang, Hong Wang, Yiting Shen, Jiahui Lai, and Jinghua Chen*. Phospholipid-Decorated Glycogen Nanoparticles for Stimuli-Responsive Drug Release and Synergetic Chemophotothermal Therapy of Hepatocellular Carcinoma. ACS Applied Materials & Interfaces 2020, 12, 20, 23311-23322. 5)Yuning Han, Bin Hu, Mingyu Wang, Yang Yang, Li Zhang,Juan Zhou*and Jinghua Chen*. pH-Sensitive Tumor-Targeted Hyperbranched System Based on Glycogen Nanoparticles for Liver Cancer Therapy. Applied Materials Today, 2020, 18, 100521. 6)Juan Zhou, Mingyu Wang, Yuning Han, Jiahui Lai, and Jinghua Chen*. Multistage-Targeted Gold/Mesoporous Silica Nanocomposite Hydrogel as in Situ Injectable Drug Release System for Chemophotothermal Synergistic Cancer Therapy. ACS Applied Bio Materials, 2020, 3, 1, 421-431. 7)Xingzhong Zhang,Juan Zhou, Jinghua Chen, Bin Li, Yan Li, Shilin Liu. Edible foam based on Pickering effect of bacterial cellulose nanofibrils and soy protein isolates featuring interfacial network stabilization. Food Hydrocolloids, 2020, 100, 105440. 8)Xihe Zhang,Juan Zhou*, Huiyan Ying, Yuting Zhou, Jiahui Lai, and Jinghua Chen*. Glycogen as a Cross-Linking Agent of Collagen and Nanohydroxyapatite to Form Hydrogels for bMSC Differentiation. ACS Sustainable Chemistry & Engineering, 2020, 8, 4, 2106-2114. 9)Huiyan Ying,Juan Zhou*, Mingyu Wang, Dandan Su, Qiaoqiao Ma, Guozhong Lv and Jinghua Chen*. In Situ Formed Collagen-Hyaluronic Acid Hydrogel as Biomimetic Dressing for Promoting Spontaneous Wound Healing. Materials Science and Engineering: C, 2019, 101, 487-498. 10)Dandan Su,Juan Zhou*, Kamel S.Ahmed, Qiaoqiao Ma, Guozhong Lv and Jinghua Chen*. Fabrication and characterization of collagen-heparin-polypyrrole composite conductive film for neural scaffold. International Journal of Biological Macromolecules, 2019, 129, 895-903. 11)Safia Naz, Muhammad Shamoon, Rui Wang, Li Zhang,Juan Zhou*and Jinghua Chen*. Advances in Therapeutic Implications of Inorganic Drug Delivery Nano-Platforms for Cancer. International Journal of Molecular Science, 2019, 20, 965-982. 12)Safia Naz, Mingyu Wang, Yuning Han, Bin Hu, Liping Teng,Juan Zhou*, Huijie Zhang* and Jinghua Chen. Enzyme Responsive Mesoporous Silica Nanoparticles for Tumor Cells and Mitochondria Multistage-Targeted Drug Delivery. International Journal of Nanomedicine, 2019, 14, 2533-2542. 13)Sheng Xie,Juan Zhou, Xuan Chen, Na Kong, Yanmiao Fan, Yang Zhang, Gerry Hamme, David G. Castner, Olof Ramström* and Mingdi Yan*. A Versatile Catalyst-Free Perfluoroaryl Azide-Aldehyde-Amine Conjugation Reaction. Materials Chemistry Frontiers, 2019, 3, 251-256. 14)Zhi Cai，Liping Teng，Juan Zhou，Yishu Yan*，Yan Zhang，Guozhong Lv，Jinghua Chen*. Design and Synthesis of a Native Heparin Disaccharide Grafted Poly 2 Aminoethyl Methacrylate Glycopolymer for Inhibition of Melanoma Cell Metastasis. International Journal of Biological Macromolecules, 2019, 126, 612-619. 15)Juan Zhou, Mingyu Wang, Huiyan Ying, Dandan Su, Huijie Zhang, Guozhong Lv and Jinghua Chen*. Extracellular Matrix Component Shelled Nanoparticles as Dual Enzyme-Responsive Drug Delivery Vehicles for Cancer Therapy. ACS Biomaterials Science & Engineering, 2018, 4, 7, 2404-2411. 16)Juan Zhou, Huiyan Ying, Mingyu Wang, Dandan Su, Guozhong Lv and Jinghua Chen*. Dual Layer Collagen-GAG Conduit that Mimic Vascular Scaffold and Promote Blood Vessel Cells Adhesion, Proliferation and Elongation. Materials Science and Engineering: C, 2018, 92, 1, 447-452. 17)Na Kong, Sheng Xie,Juan Zhou, Margarita Menendez, Dolores Solis, JaeHyeung Park, Giampiero Proietti, Olof Ramström* and Mingdi Yan*. Catalyst-Free Cycloaddition Reaction for the Synthesis of Glyconanoparticles. ACS Applied Materials & Interfaces, 2016, 8, 41, 28136-28142. 18)Qi Cai,Juan Zhou, Weiping Zhu*, Yufang Xu and Xuhong Qian. Fluorescent and MRI Bimodal Imaging Agent for Tumor Hypoxia. Nanomedicine: Nanotechnology, Biology and Medicine, 2016, 12, 2, 506. 【近5年主要授权专利】 1)一种融合蛋白纳米粒及其应用，PCT/CN2019/095707 2)一种生物粘合剂及其制备方法，ZL 201911087311.5 3)一种可储水挎包，ZL 201921437769.4 【主要奖励】 江苏省“双创博士” |
