科学研究情况简介 |
【近年来获得的学术科研成果】 主持国家自然科学基金1项,主持中央高校基本科研业务费专项资金1项,参与国家自然科学基金1项;主持企业合作项目3项,参与企业合作项目4项;指导国家及江苏省大学生创新创业训练计划项目各1项;发表论文16篇;提交发明专利申请6项。 【近年来主要研究课题】 [1]多肽/胶原蛋白互穿杂化水凝胶用于化药/蛋白共载及瘤内控释的研究(81603060),国家青年科学基金项目,主持。 [2]仿制药小试处方工艺开发,企业合作项目,主持。 [3]润眼剂、气雾剂及口腔清洁剂的开发,企业合作项目,主持。 [4]脂质纳米混悬剂工艺开发,企业合作项目,主持。 【近年来主要论文代表作】 [1]Yang Z,LiuL,SuLL, Wu XQ, Wang YC, Liu L,Lin X*.Design of a Zero-order Sustained Release PLGA Microspheres for Palonosetron Hydrochloride with High Encapsulation Efficiency.International Journal of Pharmaceutics, 2020. [2]Yang Z, Hu Y, Tang G, Dong MM, Liu Q,LinX*.Development of ibuprofen dry suspensions by hot melt extrusion: Characterization, physical stability and pharmacokinetic studies.Journal of Drug Delivery Science and Technology. 2019 [3]Lin X,Hu Y,Liu L,Su LL, Li N, Yu J, Tang B, Yang Z.Physical Stability of Amorphous Solid Dispersions: a Physicochemical Perspective with Thermodynamic, Kinetic and Environmental Aspects. Pharmaceutical Research, 2018, 35(6):125. [4]Lin X, Yang H, Su L,Yang Z, Tang X. Effect of size on the,in vitro/in vivo, drug release and degradation of exenatide-loaded PLGA microspheres. Journal of Drug Delivery Science and Technology, 2018, 45:346-356. [5]Lin X, Su L, Li N,Hu Y, Tang G, Liu L, Li H, Yang Z. Understanding the mechanism of dissolution enhancement for poorly water-soluble drugs by solid dispersions containing Eudragit® E PO. Journal of Drug Delivery Science and Technology, 2018, 48:328-337. [6]Lin X, Wang J, Xu Y, Tang X, Chen J, Zhang Y, Zhang Y, Yang Z. Tracking the effect of microspheres size on the drug release from a microsphere/sucrose acetate isobutyrate (SAIB) hybrid depot in vitro and in vivo. Drug Development and Industrial.Pharmacy. 2016, 42(9):1-27. [7]Lin X, Xu Y, Tang X, Zhang Y, Chen J, Zhang Y, He H, Yang Z. A uniform ultra-small microsphere/SAIB hybrid depot with low burst release for long-term continuous drug release. Pharmaceutical Research. 2015 Nov; 32(11):3708-3721. [8]Lin X, Zhang B, Zhang KR, Zhang Y, Wang J, Qi N, Yang SS, He HB, Tang X. Preclinical evaluations of norcantharidin-loaded intravenous lipid microspheres with low toxicity. Expert Opinion on Drug Delivery. 2012, 9(12):1449-1462. [9]Lin X, Gao R, Zhang Y, Qi N, Zhang Y, He H, Zhang K, Tang X. Lipid nanoparticles for chemotherapeutic applications: strategies to improve anticancer efficacy. Expert Opinion on Drug Delivery. 2012, 9(7):767-781. [10]Lin X, Yang S, Gou J, Zhao M, Zhang Y, Qi N, He H, Cai C, Tang X, Guo P. A novel risperidone-loaded SAIB-PLGA mixture matrix depot with a reduced burst release: effects of solvents and PLGA on drug release behaviors in vitro/in vivo. Journal of Materials Science Materials in Medicine. 2012, 23(2):443-55. [11]Lin X, Zhang Y, Cui Y, Wang L, Wang J, Tang X. Determination of alprostadil in rat plasma by ultra performance liquid chromatography-electrospray ionization-tandem mass spectrometry after intravenous administration. Journal of Pharmaceutical and Biomedical Analysis. 2009, 49(4):983-8. [12]林霞,李其彬,石晓宇,杨子毅 美金刚长效注射剂的制备及其评价.中国药科大学学报, 2018, 49(05):81-89. |