科学研究情况简介 |
【近5年来主要研究课题】 从事生物制药方向的科研、教学及生物技术与工程应用领域的实践工作，主要工作包括：1、药剂学，致力于药物新剂型的开发与应用；2、生物医用材料，主要包括胶原基体内止血材料、体内填充修复材料、牙科填充材料、骨科材料、伤口敷料，以及新一代血液透析材料、硬膜补片、人工软骨、医学美容产品的开发和应用研究；3、天然活性多糖药物的开发以及多糖聚合物的合成和功能研究，主要开展了肝素、低分子量肝素、药用真菌多糖等物质提取、制备和衍生加工，并基于细胞模型、动物模型评价体系进行功能评价。 【近5年来主持项目】 1、国家自然科学基金，仿肝素含糖高分子的合成、抗肿瘤转移活性及靶标蛋白的相互作用研究，21574059，2016-2019. 2、教育部轻工技术与工程“双一流”建设学科，LITE2018-20，糖胺聚糖及生物医用材料开发，2018-今 3、企业合作横向项目，以营养健康为导向的特膳食品开发与应用研究（52.5万）2019-2023. 4、企业合作横向项目，可吸收胶原组织修复材料的研发与产业化（200万）2017-2020. 5、企业合作横向项目，漳州片仔癀药业股份有限公司（24万）2019-2020. 6、企业合作横向项目，可塑性人工骨修复材料的研发及产业化（200万）2017-2018. 7、江苏省产学研项目，胶原基功能化牙科填充材料的研发，BY2014023-17，2014-2016. 8、江苏省“六大人才高峰”资助项目，高活性低分子量肝素原料药和人工合成肝素类似物新型抗凝血药物研发，2014-SWYY-033，2014-2017. 9、江苏省第四期“333高层次人才培养工程”（第三层次），2011-2015. 10、江苏省科技支撑计划-社会发展项目，基于静电纺丝和酶法交联的胶原基人工皮肤的研发，SBE201077350，2010-2013. 11、国家自然科学基金，表面原位合成类肝素多糖以提高生物材料血液相容性研究，50873080，2009-2011. 12、新世纪优秀人才支持计划，新型生物医用材料的研制，NCET-10-0435，2009-2012. 【近5年来代表性论文】 1、Mingyu Wang, Li Zhang, Yanfei Cai, Yang Yang, Lipeng Qiu, Yiting Shen, Jian Jin, Juan Zhou*,Jinghua Chen*. Bioengineered Human Serum Albumin Fusion Protein as Target/Enzyme/pH Three-Stage Propulsive Drug Vehicle for Tumor Therapy,ACS Nano, 2020, 14, 17405-17418. 2、Yan Zhang, Mihail Barboiu*, Olof Ramström*,Jinghua Chen*. Surface-Directed Selection of Dynamic Constitutional Frameworks as an Optimized Microenvironment for Controlled Enzyme Activation,ACS Catalysis, 2020, 10: 1423-1427. 3、JunLing Song, ZhaoQian Huang, Jing Mao, WeiJun Chen, Bin Wang, FuWei Yang, ShenHuan Liu, HuiJie Zhang, LiPeng Qiu*,JingHua Chen*. A facile synthesis of uniform hollow MIL-125 titanium-based nanoplatform for endosomal esacpe and intracellular drug delivery,Chemical Engineering Journal, 2020, 396: 125246. 4、Juan Zhou, Yuning Han, Yang Yang, Li Zhang, Hong Wang, Yiting Shen, Jiahui Lai, andJinghua Chen*. Phospholipid-Decorated Glycogen Nanoparticles for Stimuli-Responsive Drug Release and Synergetic Chemophotothermal Therapy of Hepatocellular Carcinoma,ACS Applied Materials & Interfaces, 2020, 12, 23311-23322. 5、Yan Zhang, Ye Zhang, Han Cui, Mihail Barboiu*,Jinghua Chen*. Dynameric Collagen Self-healing Membranes with High MechanicalStrength for Effective Cell Grow Applications,Chemistry-A European Journal, DOI: 10.1002/chem.202003269. 6、Xihe Zhang, Juan Zhou*, Huiyan Ying, Yuting Zhou, Jiahui Lai,Jinghua Chen*. Glycogen as a Cross-Linking Agent of Collagen and Nanohydroxyapatite To Form Hydrogels for bMSC Differentiation,ACS Sustainable Chemistry & Engineering, 2020, 8: 2106-2114. 7、Yi Liu, Rui Wang, Shayang Chen, Zhujie Xu, Qiqi Wang, Peng Yuan, Yiyi Zhou, Yan Zhang,Jinghua Chen*. Heparan sulfate loaded polycaprolactone-hydroxyapatite scaffolds with 3D printing for bone defect repair,International Journal of Biological Macromolecules, 2020, 148: 153-162. 8、Yuning Han, Bin Hu, Mingyu Wang, Yang Yang, Li Zhang, Juan Zhou*,Jinghua Chen*. pH-Sensitive Tumor-Targeted Hyperbranched System Based on Glycogen Nanoparticles for Liver Cancer Therapy,Applied Materials Today, 2020, 18, 100521. 9、Zhujie Xu, Qiqi Wang, Yuyu Jiang, Rui Wang, Shayang Chen, Jingyu Zhu, Yan Zhang*,Jinghua Chen*. Selective regulation of RANKL/RANK/OPG pathway by heparan sulfate through the binding with estrogen receptor β in MC3T3-E1 cells,International Journal of Biological Macromolecules, 2020, 161: 1526-1534. 10、Huiyan Ying, Juan Zhou, Mingyu Wang, Dandan Su, Qiaoqiao Ma, Guozhong Lv,Jinghua Chen*. In situ formed collagen-hyaluronic acid hydrogel as biomimetic dressing for promoting spontaneous wound healing,Materials Science & Engineering C-Materials for Biological Applications, 2019, 101: 487-498. 11、Shuqin Xu*, Shuyu Zhou, Baoliang Mao,Jinghua Chen*, Ziyin Zhang. Cornea-Stroma-Mimicking Films Derived from Cellulose Nanocrystal Templating Fibrous Collagen as Therapeutic Contact Lenses,ACS Sustainable Chemistry & Engineering, 2019, 7: 12248-12260. 12、Lipeng Qiu, Xiaotian Shan, Miaomiao Long, Kamel S.Ahmeda, Li Zhao, Jing Mao, HuijieZhang, Chang ling Sun, Chong zhaoYou, Guozhong Lv,JinghuaChen*. Elucidation of cellular uptake and intracellular trafficking of heparosan polysaccharide-based micelles in various cancer cells.International Journal of Biological Macromolecules, 2019, 130: 755-764. 13、Dandan Su, Juan Zhou*, Kamel S.Ahmed, Qiaoqiao Ma, Guozhong Lv,Jinghua Chen*. Fabrication and characterization of collagen-heparin-polypyrrole composite conductive film for neural scaffold.International Journal of Biological Macromolecules, 2019, 129: 895-903. 14、Huijie Zhang, Li Lai, Yalin Wang, Baoting Ye, Shuhao Deng, Airan Ding, Liping Teng, Lipeng Qiu,Jinghua Chen*.Silk Fibroin for CpG Oligodeoxynucleotide Delivery,ACS Biomaterials Science & Engineering, 2019, 5: 6082-6088. 15、Huijie Zhang, Ting Cheng, Li Lai, Shuhao Deng, Ruixi Yu, Lipeng Qiu, Juan Zhou, Guozhong Lu, Chunyi Zhi,Jinghua Chen*. BN nanospheres functionalized with mesoporous silica for enhancing CpG oligodeoxynucleotide-mediated cancer.Nanoscale, 2018, 10: 14516-14524. 16、Lipeng Qiu, Mengqin Zhu, Kai Gong,Jinghua Chen*. pH-Sensitive degradable polymeric micelles for bio-triggered targeted anti-tumor drug delivery.Journal of Controlled Release. 2017,259:e5-e195. 17、Jingxiao Chen, Wen Liu, Mao Zhang,Jinghua Chen*. Heparosan based nanocarrier for rapid intracellular drug delivery.Journal of ControlledRelease, 2015, 213: e54-5. 18、Min Wang, Rui Wang, Jingxiao Chen,Jinghua Chen*. pH-triggered drug carrier for targeted co-delivery of genes and drugs.Journal of ControlledRelease,2015, 213: e76-77. 【近5年主要授权专利】 已授权： 1、硫酸化肝素二糖接枝聚甲基丙烯酰乙醇胺的用途，发明专利号，ZL201810399166.3； 2、一种硫酸化肝素二糖接枝聚甲基丙烯酰乙醇胺及其制备方法，发明专利号，ZL201810399859.2； 3、一种猪胸主动脉中提取水不溶性胶原的方法，专利号，ZL201510237801.4； 4、一种组织工程皮肤的制备方法，专利号，ZL201510410472.9； 已公开国际专利： 1、一种融合白蛋白纳米粒及其应用，公开号，PCT/CN2019/095707；201910525910.4； 2、硫酸化肝素二糖接枝聚甲基丙烯酰乙醇胺的用途，公开号，PCT/CN2018/091470； 3、一种硫酸化肝素二糖接枝聚甲基丙烯酰乙醇胺及其制备方法，公开号，PCT/CN2018/091475； 4、一种羊膜-海绵状壳聚糖复合双层伤口敷料的制备方法，公开号，PCT/CN2019/122412 【主要奖励】 1、微生物发酵生产酸性功能多糖的关键技术与应用轻工联合会技术进步奖二等奖 2019.2 2、酸性功能多糖发酵生产与结构调控的关键技术及应用高等学校科学研究优秀成果奖科学技术进步奖二等奖 2019.1 3、微环境调控创面修复的关键技术及应用江苏医学科技奖一等奖 2018.12 4、微生物制备线性糖胺聚糖及结构调控的关键技术中国商业联合会科学技术奖一等奖 2018.12 5、生肌玉红膏及其符合改性后胶原蛋白促进慢性创面愈合系列研究中华中医药学会科学技术奖二等奖 2017.11 6、烧创伤创面修复相关材料的基础及应用研究江苏省科学技术奖二等奖 2017.2 |
