【论文及专利】 1. Determination of an isonicotinylhydrazide derivative, a novel positive inotropic compound, in mouse plasma by LC-MS/MS and its application to a pharmacokinetics study Journal of Pharmaceutical and Biomedical Analysis (2019), 165, 12-17. 2. Design, synthesis, and biological evaluation of 2-(4-(methylsulfonyl)phenyl)pyridine derivatives as GPR119 agonists Chemical Biology & Drug Design (2019), 93(1), 67-74. 3. Synthesis and biological evaluation of novel 5,6-dihydropyrimido[4,5-f]quinazoline derivatives as potent CDK2 inhibitors Bioorganic & Medicinal Chemistry Letters (2018), 28(20), 3385-3390. 4. Alkylation method of nitrogen-containing hydrogen compound and its application Faming Zhuanli Shenqing (2018), CN 108503583 A 20180907, 5. Preparation of pyrazolo[1,5-a]pyrimidine compounds as antitumor agents Faming Zhuanli Shenqing (2018), CN 108484613 A 20180904, 6. Pyrimido[4,5-f]quinazoline compounds as CDK inhibitors and their preparation, pharmaceutical compositions and use in the treatment of cancer Faming Zhuanli Shenqing (2018), CN 108484606 A 20180904, 7. Synthesis and SAR of 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivatives as potent and selective CDK4/6 inhibitors European Journal of Medicinal Chemistry (2018), 157, 935-945. 8. Pyrazolo[4,3-h]quinazoline compound and application thereof Faming Zhuanli Shenqing (2017), CN 107383019 A 20171124, 9. A polypeptide derivatization method and its application in maldi-tof-ms detection of medicine metabolites [Machine Translation]. Faming Zhuanli Shenqing (2017), CN 107085032 A 20170822, 10. Transition-Metal-Free Trifluoromethylation of Aldehyde Derivatives with Sodium Trifluoromethanesulfinate Journal of Organic Chemistry (2017), 82(18), 9384-9399. 11. 1,2,5-Thiadiazole-2-oxide analogues as schistosomicides and their preparation, pharmaceutical compositions and use in the treatment of schistosomiasis Faming Zhuanli Shenqing (2017), CN 106632142 A 20170510, 12. Method for preparing statin bulk drug intermediate with improved Julia olefination reaction as key step Faming Zhuanli Shenqing (2017), CN 106588763 A 20170426, 13. Synthesis method for chiral secondary allyl alcohol with hydroxy ortho position substituted with halogen atom Faming Zhuanli Shenqing (2017), CN 106588565 A 20170426, 14. Development and validation of pharmacophore of G protein-coupled receptor 40 agonists Jisuanji Yu Yingyong Huaxue (2017), 34(2), 157-162. 15. Gold-Oxazoline Complex-Catalyzed Cross-Dehydrogenative Coupling of Glycine Derivatives and Alkenes Advanced Synthesis & Catalysis (2017), 359(5), 824-831. 16. Synthesis of aromatic amide derivatives and their biological evaluation against protein tyrosine phosphatase 1B and protein tyrosine phosphatase SHP2 Youji Huaxue (2016), 36(9), 2142-2149. 17. Oxadiazole-2-oxides may have other functional targets, in addition to SjTGR, through which they cause mortality in Schistosoma japonicum Parasites & Vectors (2016), 9, 26/1-26/12. 18. Lead-removing polysulfide ether composition and its application in health food Faming Zhuanli Shenqing (2016), CN 105815781 A 20160803, 19. A sugar protein fluorescent probe molecules for continuous synthesis method Faming Zhuanli Shenqing (2016), CN 105806820 A 20160727, 20. Gene expression profiling of H9c2 cells subjected to H2O2-induced apoptosis with/without AF-HF001 Biological & Pharmaceutical Bulletin (2016), 39(2), 207-214. 21. Interleukin 10 protects primary melanocyte by activation of Stat-3 and PI3K/Akt/NF-κB signaling pathways Cytokine+ (2016), 83, 275-281. 22. Acyl hydrazone derivative for treating heart failure Faming Zhuanli Shenqing (2016), CN 105481765 A 20160413, 23. A Decoquinate analogue and application Faming Zhuanli Shenqing (2016), CN 105330602 A 20160217, 24. Iron-catalyzed direct α-arylation of α-amino carbonyl compounds with indoles Organic & Biomolecular Chemistry (2016), 14(5), 1550-1554. 25. Establishment and application of enzymatic assay for poly(ADP-ribose) polymerase-1 Shipin Yu Shengwu Jishu Xuebao (2015), 34(3), 324-329. 26. Immobilizing of oxo-molybdenum complex on cross-linked copolymer and its catalytic activity for epoxidation reactions Catalysis Communications (2016), 74, 1-4. 27. Continuous preparation method of 1-aminoanthraquinone Faming Zhuanli Shenqing (2015), CN 105017039 A 20151104, 28. Spiro-isoxazoline derivatives as PTP1B inhibitor and their preparation Faming Zhuanli Shenqing (2015), CN 104945416 A 20150930, 29. An efficient one-pot, three-component synthesis of vinyl sulfones via iodide-catalyzed radical alkenylation Tetrahedron (2015), 71(38), 6740-6743. 30. Benzene ring-aromatic ring in-series compound and preparation method and pharmaceutical application thereof Faming Zhuanli Shenqing (2015), CN 104788410 A 20150722, 31. Palladium(II)-Catalyzed C-H Acylation with Arylglycine Derivatives Synlett (2015), 26(14), 2033-2036. 32. Synthesis of Novel 3-aryl-1-oxa-2,8-diazaspiro[4.5]dec-2-ene Derivatives and Their Biological Evaluation Against Protein Tyrosine Phosphatase 1B Chemical Biology & Drug Design (2015), 86(5), 1161-1167. 33. TBAI-catalyzed synthesis of α-ketoamides via sp3 C-H radical/radical cross-coupling and domino aerobic oxidation Tetrahedron Letters (2015), 56(31), 4638-4641. 34. Rh(I)-catalyzed decarbonylation synthesis of carbazoles via C-N cleavage Tetrahedron (2015), 71(23), 4035-4038. 35. Palladium-Catalyzed Heck-Type Coupling via C-N Cleavage Synlett (2015), 26(9), 1253-1257. 36. Asymmetric catalytic carbon-carbon coupling reactions via cross-dehydrogenative coupling reactions Youji Huaxue (2014), 34(12), 2406-2411. 37. Iron-catalyzed oxidative phosphorylation of α-sp3-C-H bonds of N-aryl tetrahydroisoquinolines with air as oxidant Youji Huaxue (2014), 34(11), 2249-2254. 38. Method for preparing key intermediate of canagliflozin Faming Zhuanli Shenqing (2015), CN 104447678 A 20150325, 39. 2,3-Dihydroperimidine analogs and synthetic method, pharmaceutical composition and use thereof Faming Zhuanli Shenqing (2015), CN 104418811 A 20150318, 40. Method for synthesis of sodium glycididazole Faming Zhuanli Shenqing (2015), CN 104356070 A 20150218, 41. Zebrafish as a New Model for Phenotype-based Screening of Positive Inotropic Agents Chemical Biology & Drug Design (2015), 85(3), 253-258. 42. Preparation of glucoside and amino acid eutectic crystal form for treatment of glucose related disorder Faming Zhuanli Shenqing (2015), CN 104292221 A 20150121, 43. Method for preparing erysovine monomer from Vaccaria segetalis seeds Faming Zhuanli Shenqing (2014), CN 104030965 A 20140910, 44. Preparation of 1,2,5-oxadiazole-2-oxide analogs and useful in the treatment of schistosomiasis Faming Zhuanli Shenqing (2014), CN 104003954 A 20140827, 45. Preparation of praziquantel analogs as anti-schistosomiasis drugs Faming Zhuanli Shenqing (2014), CN 103910725 A 20140709, 46. Synthesis and evaluation of the anti-schistosoma activity against S. japonicum of 1-methyl-1,2,3,4-tetrahydroisoquinoline derivatives Youji Huaxue (2013), 33(12), 2588-2595. 47. Synthesis and biological evaluation of novel bis-aromatic amides as novel PTP1B inhibitors Bioorganic & Medicinal Chemistry Letters (2014), 24(8), 1889-1894. 48. 1H-2,3-dihydroperimidine derivatives: a new class of potent protein tyrosine phosphatase 1B inhibitors Molecules (2014), 19(1), 102-121, 20 pp.. 49. Imidazo[4,5-b]pyridine inhibitors of B-Raf kinase Bioorganic & Medicinal Chemistry Letters (2013), 23(21), 5896-5899. 50. Synthesis and SAR studies of praziquantel derivatives with activity against Schistosoma japonicum Molecules (2013), 18, 9163-9178. 51. Synthesis and antiviral activity of conformational analogues of leucamide A Molecules (2012), 17, 14522-14530. 52. Gold-catalyzed direct indolation of tetrahydroisoquinolines Chinese Journal of Chemistry (2012), 30(12), 2741-2746. 53. Au(III)-catalyzed intermolecular amidation of benzylic C-H bonds Organic & Biomolecular Chemistry (2012), 10(46), 9137-9141. 54. Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152) Journal of Medicinal Chemistry (2012), 55(9), 4101-4113. 55. Pyrazolopyridine inhibitors of B-RafV600E. Part 2: Structure-activity relationships Bioorganic & Medicinal Chemistry Letters (2011), 21(18), 5533-5537. 56. Pyrazolopyridine Inhibitors of B-RafV600E. Part 1: The Development of Selective, Orally Bioavailable, and Efficacious Inhibitors ACS Medicinal Chemistry Letters (2011), 2(5), 342-347. 57. N-Pyrrolo[2,3-b]pyridinyl benzamide derivatives as Raf inhibitors and their preparation, pharmaceutical compositions and use in the treatment of diseases PCT Int. Appl. (2009), WO 2009111278 A2 20090911, 58. N-Pyrazolo[3,4-b]pyridinyl benzamide derivatives as Raf inhibitors and their preparation, pharmaceutical compositions and use in the treatment of diseases PCT Int. Appl. (2009), WO 2009111279 A1 20090911, 59. N-(6-Aminopyridin-3-yl)-3-(sulfonamido)benzamide derivatives as b-Raf inhibitors for the treatment of cancer and their preparation PCT Int. Appl. (2009), WO 2009111280 A1 20090911, 60. Imidazo[4,5-b]pyridine derivatives used as Raf inhibitors and their preparation and use in the treatment of diseases PCT Int. Appl. (2009), WO 2009111277 A1 20090911, 61. Methods and compositions utilizing quinazolinones as KSP kinesin inhibitors and their preparation U.S. Pat. Appl. Publ. (2008), US 20080182864 A1 20080731, 62. Evaluation of Assay Technologies for the Identification of Protein-Peptide Interaction Antagonists Assay and Drug Development Technologies (2007), 5(4), 501-514. 63. Preparation of peptides as inhibitors of IAP proteins U.S. Pat. Appl. Publ. (2006), US 20060014700 A1 20060119, 64. Heterocyclic self-immobilative linkers and conjugates PCT Int. Appl. (2005), WO 2005082023 A2 20050909, 65. 2-[1-(Imidazol-1-yl)alkyl]-3H-quinazolin-4-one derivatives, pharmaceutical compositions containing them, and methods of their use as KSP kinesin inhibitors for the treatment of cellular proliferative diseases PCT Int. Appl. (2003), WO 2003097053 A1 20031127, 66. Preparation of chromones as KSP kinesin inhibitors PCT Int. Appl. (2003), WO 2003088903 A2 20031030, 67. Compositions and methods using cardiac sarcomere-modulating benzenesulfonamide derivatives for treating heart failure, and preparation thereof PCT Int. Appl. (2003), WO 2003059265 A2 20030724, 68. Compositions and methods using arylamide compounds for treating heart failure PCT Int. Appl. (2003), WO 2003059258 A2 20030724, 69. Mitotic kinesin-targeted antitumor agents: Discovery, lead optimization and anti-tumor activity of a series of novel quinazolinones as inhibitors of kinesin spindle protein (KSP) Abstracts of Papers, 223rd ACS National Meeting, Orlando, FL, United States, April 7-11, 2002 (2002), MEDI-249. 70. Preparation of N-acylquinazolinonealkylamines as KSP kinesin inhibitors PCT Int. Appl. (2001), WO 2001098278 A1 20011227, 71. Methods and compositions utilizing quinazolinones as KSP kinesin modulators PCT Int. Appl. (2001), WO 2001030768 A1 20010503, 72. Preparation of isoquinolonecarboxylates and related compounds as immunosuppressive agents. PCT Int. Appl. (1999), WO 9938846 A1 19990805, 73. Combinatorial methods for developing complex molecular scaffolds: Application to the design of carbohydrate mimetic libraries as potential chemotherapeutics Book of Abstracts, 216th ACS National Meeting, Boston, August 23-27 (1998), MEDI-197. 74. Total synthesis of rhizoxin D Tetrahedron Letters (1997), 38(39), 6825-6828. 75. Biosyntheses of host-selective toxins produced by Alternaria alternata pathogens. I: (8R,9S)-9,10-epoxy-8-hydroxy-9-methyl-deca-(2E,4Z,6E)-trienoic acid as a biological precursor of AK-toxins Agricultural and Biological Chemistry (1990), 54(3), 845-8. 76. Structures of flazin and YS, highly fluorescent compounds isolated from Japanese soy sauce Tetrahedron Letters (1986), 27(29), 3399-402. 77. Determination of the average molecular weight of linear alkylbenzenesulfonates by ion-pair reversed-phase high-performance liquid chromatography Fenxi Huaxue (1985), 13(5), 368-70. |