【近年来获得的学术科研成果】 主持国家自然科学基金1项,江苏省“双创人才”,江苏省“科技副总”;主持企业合作项目6项;指导国家及江苏省大学生创新创业训练计划项目各1项;发表多篇SCI论文;提交发明专利申请6项。 【近年来主要研究课题】 [1] 2015 江苏省“双创人才” [2] 2016国家自然科学基金青年基金 [3] 麦考酚钠肠溶片研发,企业合作项目,无锡福祈制药有限公司,主持 [4] 盐酸文拉法辛缓释胶囊、达比加群酯胶囊一致性评价,企业合作项目,北京万生药业有限公司,主持 [5] 钙片工艺耐用性提升及粉末直压法技术开发,企业合作项目,无限极(中国)有限公司,主持 [6] 紫草婴儿软膏研究开发,企业合作项目,云南希陶绿色药业有限公司,主持 [7] 泊沙康唑肠溶片研发,企业合作项目,无锡福祈制药有限公司,主持 [8] 凯爱瑞(Kerry)配料贸易有限公司技术咨询顾问 【近年来主要论文代表作】 [1] Z. Yang, L. Liu, L.L. Su, X.Q. Wu, Y.C. Wang, L. Liu, X. Lin *. Design of a Zero-order Sustained Release PLGA Microspheres for Palonosetron Hydrochloride with High Encapsulation Efficiency. International Journal of Pharmaceutics, 2020. [2] Z. Yang, Hu Y, Tang G, Dong MM, Liu Q, X. Lin *. Development of ibuprofen dry suspensions by hot melt extrusion: Characterization, physical stability and pharmacokinetic studies. Journal of Drug Delivery Science and Technology. 2019. [3] Z. Yang and D.Q.M. Craig. Monitoring film coalescence from aqueous polymeric dispersions using atomic force microscopy: Surface topographic and nano-adhesion studies. Asian Journal of Pharmaceutical Sciences(2018). [4] X. Lin, H. Yang, L. Su, Z. Yang, and X. Tang. Effect of size on the in vitro/in vivo drug release and degradation of exenatide-loaded PLGA microspheres. Journal of Drug Delivery Science and Technology. 45:346-356 (2018). [5] X. Lin, L. Su, N. Li, Y. Hu, G. Tang, L. Liu, H. Li, and Z. Yang. Understanding the mechanism of dissolution enhancement for poorly water-soluble drugs by solid dispersions containing Eudragit® E PO. Journal of Drug Delivery Science and Technology. 48:328-337 (2018). [6] X. Lin, Y. Hu, L. Liu, L. Su, N. Li, J. Yu, B. Tang, and Z. Yang. Physical Stability of Amorphous Solid Dispersions: a Physicochemical Perspective with Thermodynamic, Kinetic and Environmental Aspects. Pharmaceutical Research. 35:125 (2018). [7] X. Lin, J. Wang, Y. Xu, X. Tang, J. Chen, Y. Zhang, Y. Zhang, and Z. Yang. Tracking the effect of microspheres size on the drug release from a microsphere/sucrose acetate isobutyrate (SAIB) hybrid depot in vitro and in vivo. Drug Development and Industrial Pharmacy. 42:1455-1465 (2016). [8] Z. Yang, K. Nollenberger, J. Albers, D. Craig, and S. Qi. Molecular Indicators of Surface and Bulk Instability of Hot Melt Extruded Amorphous Solid Dispersions. Pharmaceutical Research. 32:1210-1228 (2015). [9] X. Lin, Y. Xu, X. Tang, Y. Zhang, J. Chen, Y. Zhang, H. He, and Z. Yang. A Uniform Ultra-Small Microsphere/SAIB Hybrid Depot with Low Burst Release for Long-Term Continuous Drug Release. Pharmaceutical Research. 32:3708-3721 (2015). [10] Z. Yang, K. Nollenberger, J. Albers, and S. Qi. Molecular Implications of Drug–Polymer Solubility in Understanding the Destabilization of Solid Dispersions by Milling. Molecular Pharmaceutics. 11:2453-2465 (2014). [11] Z. Yang, K. Nollenberger, J. Albers, J. Moffat, D. Craig, and S. Qi. The effect of processing on the surface physical stability of amorphous solid dispersions. European Journal of Pharmaceutics and Biopharmaceutics. 88:897-908 (2014). [12] Z. Yang, K. Nollenberger, J. Albers, D. Craig, and S. Qi. Microstructure of an Immiscible Polymer Blend and Its Stabilization Effect on Amorphous Solid Dispersions. Molecular Pharmaceutics. 10:2767-2780 (2013). |