科学研究情况简介 |
【近5年来主要研究课题】 1、主要从事胆汁酸等活性成分在消化性疾病发生发展中机制研究，研究兴趣主要集中在胆汁酸合成、代谢与消化性疾病相互关系及相关药物筛选。 2、药源性肝脏毒性及其分子机制研究。 【近5年来主持项目】 1. S1PR2信号通路调控胆汁淤积性肝纤维化进展的机制研究，国家自然科学基金青年基金项目 2.胆汁酸通过S1PR2通路诱导急性胰腺炎腺泡细胞炎症损伤的机制研究，江苏省自然基金青年项目 【近5年来代表性论文】 1.Yongqing Wang#, Hiroaki Aoki#,Jing Yang#, Kesong Peng, Runping Liu, Xiaojiaoyang Li, Xiaoyan Qiang, Lixin Sun, Emily C Gurley, Guanhua Lai, Luyong Zhang, Guang Liang, Masayuki Nagahashi, Kazuaki Takabe, William M Pandak, Phillip B. Hylemon and Huiping Zhou, The role of S1PR2 in bile acid-induced cholangiocyte proliferation and cholestasis-induced liver injury in mice,Hepatology, 2017, 65(6): 2005-2018. 2.Jing Yang, Lixin Sun, Lu Wang, Hozeifa M. Hassan, Xuan Wang, Phillip B. Hylemon, Tao Wang, Huiping Zhou, Luyong Zhang and Zhenzhou Jiang, Activation of Sirt1/FXR Signaling Pathway Attenuates Triptolide-Induced Hepatotoxicity in Rats,Frontiers in pharmacology, 2017, 8: 260. 3.Jing Yang, Yun-zhou Li, Phillip B. Hylemon, Lu-yong Zhang, Hui-ping Zhou, Cordycepin inhibits LPS-induced inflammatory responses by modulating NOD-Like Receptor Protein 3 inflammasome activation,Biomedicine & Pharmacotherapy, 2017, 95: 1777-1788. 4.Xiaojiaoyang Li, Runping Liu,Jing Yang, Lixin Sun, Luyong Zhang, Zhenzhou Jiang, Puneet Puri, Emily C. Gurley, Guanhua Lai, Yuping Tang, Zhiming Huang, William M Pandak, Phillip B. Hylemon, Huiping Zhou. The role of long noncoding RNA H19 in gender disparity of cholestatic liver injury in multidrug resistance 2 gene knockout mice,Hepatology. 2017.9, 66(3): 869~884. 【近5年主要授权专利】 【主要奖励】 |
