科学研究情况简介
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【近年来获得的学术科研成果】 主持并重点参与多项863项目子课题、国家自然科学基金、江苏省自然科学基金等科研项目以及企业横向合作课题，在国内外学术期刊上发表论文20余篇，申请国家发明专利20余项，其中授权10余项。 【近年来主要研究课题】 （1）863 项目子课题（2012AA022204）； （2）国家自然科学基金（21206055）； （3）江苏省自然科学基金（BK2012127）； （4）江苏省产学研联合创新资金（BY2016022-19）。
【近年来主要论文代表作】 [1] Zheng Jialin, Li Heng, Zhang Xiaojuan, Jiang Min, Luo Chunqin, Lu Zhenming, Xu Zhenghong, Shi Jinsong*. Prebiotic Mannan-Oligosaccharides Augment the Hypoglycemic Effects of Metformin in Correlation with Modulating Gut Microbiota. Journal of Agricultural and Food Chemistry, 2018, 66, 5821-5831. [2] Jiang Min, Li Heng, Shi Jinsong*, Xu Zhenghong. Depolymerization konjac glucomannan:preparation and application in health care. Journal of Zhejiang University-SCIENCE B, 2018,19(7): 505-514. [3] Li Li#, Li Heng#, Qian Jianying, He Yongfeng, Zheng Jialin, Lu Zhenming, Xu Zhenghong, Shi Jinsong*. Structural and Immunological Activity Characterization of a Polysaccharide Isolated from Meretrix meretrix Linnaeus. Marine Drugs, 2016, 14(1): 6. [4] Gong Jinsong, Li Heng, Lu Zhenming, Zhang Xiaojuan, Zhang Qiang, Yu Jianghong, Zhou Zhemin, Shi Jinsong, Xu Zhenghong*. Engineering of a fungal nitrilase for improving catalytic activity and reducing by-product formation in the absence of structural information. Catalysis Science and Technology, 2016, 6: 4134-4141. [5] Jiang Min, Li Heng, Wang Miao, Luo Chunqin, Xu Zhenghong, Shi Jinsong*, Ma Yanhe. Subchronic toxicity and genotoxicity assessment of low molecular mass Konjac mannan oligosaccharide in vitro and in vivo. Progress in Biochemistry and Biophysics, 2016, 43(3): 271-280. [6] Li Heng#, Yang Tao#, Gong Jinsong, Xiong Lei, Lu Zhenming, Li Hui, Shi Jin-Song, Xu Zheng-Hong*. Improving the catalytic potential and substrate tolerance of Gibberella Intermedia nitrilase by whole-cell immobilization. Bioprocess and Biosystems Engineering, 2015, 38(1) : 189-197.
[7] Li Heng#, Fei Zhong#, Gong Jinsong, Yang Tao, Xu Zhenghong, Shi Jin-Song*. Screening and characterization of a highly active chitosanase based on metagenomic technology. Journal of Molecular Catalysis B: Enzymatic, 2015, 111: 29-35. [8] Gong Jinsong, Li Heng, Lu Zhenming, Shi Jinsong, Xu Zhenghong. Recent progress in the application of nitrilase in the biocatalytic synthesis of pharmaceutical intermediates. Progress in Chemistry, 2015, 27, 448-458. [9] Li Heng#, Fu Zhenzhen#, Li Hui, Zhang Xiaomei, Shi Jin-Song, Xu Zhenghong*. Enhanced biotransformation of dehydroepiandrosterone to 3β,7α,15α-trihydroxy-5-androsten-17-one with Gibberella intermedia CA3-1 by natural oils addition. Journal of Industrial Microbiology and Biotechnology, 2014, 41(10): 1497-1504. [10] Gong Jinsong, Li Heng, Zhu Xiaoyan, Lu Zhenming, Wu Yan, Shi Jinsong, Xu Zhenghong. Fungal His-tagged nitrilase from Gibberella intermedia: Gene cloning, heterologous expression and biochemical properties. PLoS ONE, 2012, 7(11): e50622. [11] 郝瑶, 李恒*, 龚劲松, 蒋敏, 许正宏, 史劲松. 重组褐藻胶裂解酶表达体系的构建及诱导条件优化. 南京中医药大学学报, 2018, 34(3): 227-231. [12] 李恒, 朱思婷, 刘旭梅, 龚劲松, 蒋敏, 许正宏, 史劲松. 褐藻胶裂解酶产生菌的分离鉴定及产酶发酵优化. 中国生物工程杂志, 2014, 34(9): 94-101.
【主要授权国家发明专利】 [1] 李恒, 史劲松, 杨涛, 龚劲松, 许正宏, 孙文敬, 周强. 复合材料固定化赤霉菌制备烟酸的方法,ZL2013100631894. [2] 李恒, 王其松, 杨生桂, 钱建瑛, 史劲松, 许正宏. 一种利用微生态菌剂固态发酵转化虾蟹废弃生物质清洁化生产甲壳素的工艺, ZL 2013100062573. [3] 史劲松, 李恒, 杨涛, 龚劲松, 许正宏, 孙文敬, 周强. 一种固定化赤霉菌并用于生物转化制备烟酸的方法, ZL 2012105383720. [4] 许正宏, 朱小燕, 李恒, 史劲松, 龚劲松, 钱建瑛, 孙文敬, 周强. 一种腈水解酶及其基因序列与应用方法, ZL 201210433096.1. [5] 许正宏, 史劲松, 李会, 李恒, 张旦旦, 许鸿瑜. 一种7α,15α 双羟化DHEA P450 酶基因的克隆及分析, ZL 201310570323X.
主要科研奖励】
（1）2017年度中国商业联合会科学技术一等奖（排名2）；（2）第八届国药工程-东富龙杯全国大学生制药工程设计竞赛一等奖（指导教师排名1）.
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