英国威廉希尔体育公司_WilliamHill-中文官网

【学术简介】

〖学习经历〗
           2009.10～2013.07   英国 University of East Anglia，博士

2007.09～2009.09   沈阳药科大学药剂学专业，硕士

2003.09～2007.07   沈阳药科大学药剂学专业，学士

〖工作经历〗
           2013.8～2014.9 英国 University College London 威廉希尔体育，博士后

【研究领域】

[1] 难溶性药物新剂型的构建，分子分散态药物传递系统机理研究及产业化。

[2] 口服缓控释药物传递系统设计与产品开发。

[3] 纳米晶体、纳米脂质微球等微粒型药物传递系统设计及应用。

【主要论著】

[1]  Yang,       Z.; Nollenberger, K.; Albers, J.; Craig, D.; Qi, S. Molecular       indicators of the surface and bulk instabilities of hot melt extrudated       amorphous solid dispersions. Pharmaceutical Research. 2014,        32, (4), 1210-1228.

[2]  Yang,       Z.; Nollenberger, K.; Albers, J.; Moffat, J. G.;Craig, D.; Qi, S. The       effect of processing on the surface physical stability of amorphous solid       dispersions. European Journal of Pharmaceutics and Biopharmaceutics. 2014,       88, (3), 897-908.

[3]  Yang,       Z.;Nollenberger, K.; Albers, J.;Qi, S. Molecular implications of       drug-polymer solubility in understanding the de-stabilisation of solid       dispersions by milling. Molecular Pharmaceutics.  2014, 11,       (7), 2453-65.

[4]  Yang, Z.;       Nollenberger, K.; Albers, J.; Craig, D.; Qi, S. Microstructure of an       Immiscible Polymer Blend and Its Stabilization Effect on Amorphous Solid       Dispersions. Molecular Pharmaceutics. 2013, 10, (7), 2767-2780

[5]  Yang, Z. Y.; Wang,       L.; Tang, X.  Determination of       azithromycin by ion-pair HPLC with UV detection. Journal of       Pharmaceutical and Biomedical Analysis. 2009, 49, (3), 811-815.

[6]  Yang, Z. Y.; Lu,       Y.; Tang, X.  Pseudoephedrine       Hydrochloride Sustained-Release Pellets Prepared by a Combination of       Hot-Melt Subcoating and PolymerCoating. Drug Development and       Industrial Pharmacy. 2008, 34, (12), 1323-1330.

[7]  Ng, Y. C.; Yang, Z.;       McAuley, W. J.; Qi, S.  Stabilisation       of amorphous drugs under high humidity using pharmaceutical thin films. European       Journal of Pharmaceutics and Biopharmaceutics. 2013, 84, (3), 555-565

[8]  Qi, S.; Moffat, J. G.; Yang,       Z. Early Stage Phase Separation in Pharmaceutical Solid Dispersion       Thin Films under High Humidity: Improved Spatial Understanding Using       Probe-Based Thermal and Spectroscopic Nanocharacterization Methods. Molecular       Pharmaceutics. 2013, 10, (3), 918-930.

[9]  Lu, Y.; Zhang, Y.; Yang,       Z.; Tang, X.  Formulation of an       intravenous emulsion loaded with a clarithromycin–phospholipid complex       and its pharmacokinetics in rats. International Journal of       Pharmaceutics. 2009, 366, (1–2), 160-169.

[10] Qi, S.; McAuley, W. J;Yang, Z.;Tipduangta,       P.Stabilization of low molecular weight amorphous       drugs in the solid state: A material science approach. Accepted by       Therapeutic Delivery-Future Science.

【科研成果及奖励】

杨子毅，现为威廉希尔体育药剂学副教授，一直专注于药物新剂型开发、新型药物传递系统构建及理论研究、新药申报等工作，注重创新技术的产品转化。从攻读硕士研究生阶段开始，便参与或负责新药申报、药物制剂技术的产业化：负责开发氯雷伪麻缓释微丸的处方设计及产业化研究；参与开发SFDA3.1类新药阿奇霉素滴眼液，品种已获得临床批件。在英国攻读博士学位及从事博士后研究期间，主要从事胶态分散系药物传递系统的剂型机理、处方构建、稳定性影响因素等方面的研究，特别对难溶性药物増溶、提高口服生物利用度这一药剂学领域的难题有独到的见解。已发表SCI论文9篇（第一作者6篇），参加国际性学术会议6次。