科学研究情况简介
|
【近年来获得的学术科研成果】
主要授权和公开专利：1.高光学纯匹伐他汀钙关键中间体的制备方法 张兆国; 姚莹; 范为正; 诸吕锋; 谢小敏. CN
102174039A
2.制备光学纯的2-羟基-4-芳基-丁酸乙酯的方法 张兆国; 孟庆华; 范为正; 张宏伟. CN
101391960A
3.利用不对称氢化制备匹伐他汀钙原料药的方法 张兆国; 范为正; 孟庆华. CN
101386592A
【近年来主要研究课题】
1. 金属催化
2. 不对称催化
3. 药物及其中间体合成工
【近年来主要论文代表作】
1. Tao, X.; Li, W.; Ma, X.; Li, X.; Fan, W.;Xie, X.; Ayad, T.; Ratovelomanana-Vidal, V. *; Zhang, Z.* Ruthenium-Catalyzed Enantioselective Hydrogenation of Aryl-Pyridyl Ketones, J. Org. Chem.2012, 77, 612-616.
2.Li, W.; Xie, X.; Tao, X.; Ma, X.; Fan, W.;Li, X.; Zhang, Z.* RuCl2(PPh3)(3)-catalyzed chemoselective hydrogenation of β,δ-diketo acid derivatives at the β-carbonyls, RSC Advances,2012, 2, 3214-3216.
3.Li, W.; Fan, W.;Ma, X.; Tao, X.; Li, X.; Xie, X.; Zhang, Z.* Ru-catalyzed hydrogenation of 3,5-diketo amides: simultaneous control of chemo- and enantioselectivity, Chem. Commun.2012, 48, 8976-8978.
4. Ma, X.; Li, W.; Li, X.; Tao, X.; Fan, W.;Xie, X.; Ayad, T.; Ratovelomanana-Vidal, V.; Zhang, Z.* Ru-catalyzed highly chemo- and enantioselective hydrogenation of γ-halo-γ,δ-unsaturated-β-keto esters under neutral conditions, Chem. Commun.2012, 48, 5352-5354.
5. 马欣, 李万方, 范为正, 陶晓明, 李晓明, 姚莹, 诸吕锋, 陈厚和, 谢小敏, 张兆国多官能团羰基化合物的高选择性不对称氢化, 有机化学. 2012, 31, 1353-1358.
6. Fan, W.;Li, W.; Ma, X.; Tao, X.; Li, X.;
Yao
, Y.; *Xie, X.; Zhang, Z.* Acid-labile δ-ketal-β-hydroxy esters by asymmetric hydrogenation of corresponding δ-ketal-β-keto esters in the presence of CaCO3, Chem. Commun.2012, 48, 4247-4249.
7. Li, X.; Ma, X.; Li, W.; Tao, X.; Meng, Q.; Fan, W.;Zhang Z.* Catalytic Asymmetric Hydrogenation of Ethyl 2-(Benzo[b]thiophen-5-yl)-2-oxoacetate with Ru-SunPhos in the Formal Synthesis of T-588, Chinese Journal of Chemistry, 2012, 29, 2581-2583.
8. Fan, W.;Li, W.; Ma, X.; Tao, X.; Li, X.;
Yao
, Y.; Xie, X.; Zhang, Z.* Ru-Catalyzed Asymmetric Hydrogenation of γ-Heteroatom Substituted beta-Keto Esters, J. Org. Chem.2011, 76, 9444-9451.
9.Zhu, L.; Chen, H.;* Meng, Q.; Fan, W.;Xie, X.; Zhang, Z.* Highly enantioselective hydrogenation of 2-oxo-4-arybutanoic acids to 2-hydroxy-4-arylbutanoic acids, Tetrahedron, 2011, 67, 6186-6190.
10.Li, W.; Ma, X.; Fan, W.;Tao, X.; Li, X.; Xie, X, *Zhang, Z.* Ru-Catalyzed Asymmetric Hydrogenation of 3-Oxoglutaric Acid Derivatives via Solvent-Assisted Pinpoint Recognition of Carbonyls in Close Chemical Propinquity, Org. Lett.2011, 13, 3876-3879.
11.Yao, Y.; Fan, W.;Li, W.; Ma, X.; Zhu, L.; Xie, X.; Zhang, Z.* Synthesis of (S)-7-Amino-5-azaspiro[2.4]heptane via Highly Enantioselective Hydrogenation of Protected Ethyl 1-(2-Aminoaceto)cyclopropanecarboxylates, J. Org. Chem.2011, 76, 2807-2813.
12. Zhu, L.; Meng, Q.; Fan, W.;Xie, X.; Zhang, Z.* Direct Asymmetric Hydrogenation of 2-Oxo-4-arylbut-3-enoic Acids, J. Org. Chem.2010, 75, 6027-6030.
13. Ma X.; Fan W.;Li X.;
Yao
Y.;Zhang Z.* Asymmetric Catalytic Reactions under Solvent-Free Conditions, Progress in Chemistry, 2010, 22, 1310-1340.
14. Wan, X.; Meng Q.; Zhang H.; Sun Y.; Fan W.; Zhang Z.* An Efficient Synthesis of Chiral β-Hydroxy Sulfones via Ru-Catalyzed Enantioselective Hydrogenation in the Presence of Iodine, Org. Lett.2007, 9, 5613–5616.
|
