Zhaoqi Yang, Ph.D.
Associate Professor
School of Pharmaceutical Sciences
Jiangnan University
Email: zhaoqiyang@jiangnan.edu.cn
Education and Professional Experiences
Dr. Zhaoqi Yang received his master degree in major of medicinal chemistry from Wuhan University in 2005. Then, he joined in College of Pharmacy at Jinan University to work as a lecturer from 2005 to 2008. After three years working experiences in Jinan University, he pursued his Ph.D. degree in the Division of Chemistry and Biological Chemistry at Nanyang Technological University (NTU) supported by a research scholarship provided by NTU. After he earned his Ph.D. degree, he worked as a postdoctoral fellow in the Division of Chemistry and Biological Chemistry at NTU in 2012. From Nov to Dec in 2012, he worked as visiting scholar in Hong Kong University of Science and Technology. In Jan 2013, he joined the faculty as associate professor in the School Food Science and Technology at Jiangnan University. From Jan 2017, he transferred to School of Pharmaceutical Sciences in same university.
Research Achievements
The major focuses of his research is chemical biology with emphasis on the DNA structure and function. Most importantly, he has discovered that Human topoisomerase I could recognize the forcible curvature of DNA, which is one of the greatest breakthroughs in the field of topoisomerase in recent years. On account of his excellent research, more than forty papers have been published over the past several years, including four papers in Chemical Communications, four papers in Bioorganic & Medicinal Chemistry Letters, and so on. In addition, he is a member of Royal Society of Chemistry and Chinese Chemical Society, and the principle investigator on Natural Science Foundation of China Grant, the Grant for the Returned Overseas Scholars of Ministry of Education and so on, as well as the referee for some journals related to chemistry and pharmaceutical sciences.
Research Interests
DNA structure and function
Topoisomerase and anti-cancer drug
Drug design and synthesis
Nucleic acid chemistry
Awarded Research Grants
1. Fok Ying-Tong Education Foundation
2. Six talent peaks project in Jiangsu Province
3. The Key Project for the Scientific and Technological Activities of Returned Overseas Chinese Scholar in Wuxi
4. Natural Science Foundation of China
5. Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry
6. Jiangsu Province Doctoral Research Plan for the Talent form World's Famous Universities
7. Natural Science Foundation of Jiangsu Province
8. Fundamental Research Funds for the Central Universities
Selected Publications
1. Yang, Z.Q.*; Jiang T.Y.; Zhong, H.S.; Kang Y. Bulge Oligonucleotide as an Inhibitory Agent of Bacterial Topoisomerase I. J. Enzyme. Inhib. Med. Ch., 2018, 33,319-323.
2. Yang, Z.Q.*; Jiang T.Y.; Zhong, H.S.; Liu, Y.F. Portion mismatch in duplex oligonucleotides as inhibitors of bacterial topoisomerase I. RSC Adv., 2016, 6, 107572-107576.
3. Yang, Z.Q.*; Tang X.S.; Liu, Y.F. Enhanced performance of dye-sensitized solar cells with fluorine doped nanocrystalline TiO2 as photoanode. Electrochim. Acta, 2015, 186, 151-156.
4. Yang, Z.Q.*; Liu, Y.F. Truncated Au decahedron by the time induced truncating. Nanosci. Nanotech. Lett., 2015, 7(8), 685-689.
5. Yang, Z.Q.*; Chen, W.W.; Zu, Z.Q.; Zang, Z.Q.; Yang, Y.C; Tang, X.S.* Facile synthesis and photoluminescence characterization of AgInZnS hollow nanoparticles. Mater. Lett., 2015, 151, 89-92.
6. Yang, Z.Q.; Li, D.W.; Guo, J.J.; Shao, F.W.; Li, T.H. Intrinsic curvature in duplex DNA inhibits Human Topoisomerase I. Bioorg. Med. Chem. Lett., 2012, 22(3), 1322-1325.
7. Yang, Z.Q.; Li, D.W.; Li, T.H. Design and synthesis of catenated rings based on toroidal DNA structures. Chem.Comm., 2011, 47 (43), 11930 -11932.
8. Yang, Z.Q.; Li, D.W.; Hiew, S.H.; Ng, T.T.M.; Yuan, W.X.; Su, H.B.; Shao, F.W.; Li, T.H. Recognition of forcible curvature in circular DNA by human topoisomerase I. Chem.Comm., 2011, 47 (40), 11309-11311.
9. Li, D.W.; Li, W.L.; Wang, Q.; Yang, Z.Q.*; Hou, Z.J. Concise Synthesis of Cannabisin G. Bioorg. Med. Chem. Lett., 2010, 20(17), 5095-5098.
10. Wong, W. C.; Zhuang, J.Y.; Ng, L.L.S.; New, L.L.L.; Hiew, S.H.; Guo, J.J.; Yang, Z.Q.*; Li, T.H. Conformational organizations of G-quadruplexes composed of d(G4Tn)3G4. Bioorg. Med. Chem. Lett., 2010, 20, 4689-4692.
11. Yang, Z.Q.; Sun, P.; Chen, W.M. 3D-QSAR Analysis on Pyrrolopyridine analogs as Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MK-2) inhibitors. Lett. Drug Des. Discovery, 2007, 4(8), 557-561.
12. Yang, Z.Q.; Sun, P. 3D-QSAR study of Potent Inhibitor of Phosphodiesterase-4 by using CoMFA approach. Int. J. Mol. Sci. 2007, 8(7), 714-722.
